李艳辉教授 简介

李艳辉，女，博士，1976年2月出生，厦门理工学院教授、长春理工大学材料学专业博士生导师，吉林省第八批拔尖创新人才。兼任厦门市聚合物加工原理与应用重点实验室主任。2000、2002和2006年获哈尔滨工业大学高分子材料与工程专业学士学位、材料学专业硕士学位，应用化学专业博士学位。2008年和2014年分别晋升副教授和教授职称。

近年来主要从事生物医用高分子设计与合成、基于高分子的基因/药物传输体系、高分子抗菌材料、高分子杂化光催化剂的研究等方面的研究工作，先后主持了国家自然科学基金项目、吉林省科技发展计划项目、吉林省教育厅科学技术研究规划重大和“十三五”科学技术项目、中国博士后科学基金等项目。现正主持国家自然科学基金面上项目、吉林省教育厅科学技术研究规划重大项目、吉林省科技发展计划面上项目等。近五年在Adv Mater、Adv Funct Mater、Nat Commun、Nano Lett、Nano Today、Biomaterials、J Hazard Mater、J Control Release、Chem Eng J等学术期刊发表论文80余篇，其中中科院I区论文10余篇；出版了专著3部。获吉林省科技进步二等奖1项，三等奖1项，其它省、市奖励3项。

特点：

1、立足材料前沿科学领域，关注功能高分子材料发展的最新方向，开展交叉学科的科研工作；

2、以光物理光化学为基础，开发能够吸收光子产生光化学反应的高分子光敏材料，既可以应用在生物医用领域中的光动力抗肿瘤和抗菌治疗，又可以用做光催化剂，进行相应的光氧化和光还原，用于环保、能源、检测等领域，例如光催化产氢、光催化产过氧化氢等；

3、开发新型的高分子基因/药物传输体系，实现基因和药物的担载并进行肿瘤和免疫治疗，应对国外在该领域的垄断，打破瓶颈，获得新型的载体材料，拟解决临床实际面临的问题；

4、设计多功能纳米杂化光催化剂，有机的结合高分子与无机或金属纳米材料，取长补短，开发高分子材料更广阔的性能优势，提升纳米光催化剂的理化性能，赋予其新的功能，推广应用。

主要研究领域：

1. 生物医用高分子的设计与合成

2. 高分子基因/药物载体材料

3. 高分子抗菌材料

4. 高分子杂化光催化剂

   近年来承担的主要科研项目：

5. 厦门理工学院高层次人才项目（YKJ22052R）：高分子纳米抗菌材料，2022.11～2025.10，20万，主持。

6. 国家自然科学基金面上项目（52173115）：用于抗菌治疗的纳米光敏剂的构建与研究，2022.01～2025.12，主持。

7. 国家自然科学基金面上项目（52073278）：具有可控解离性能的多功能纳米颗粒的构建及联合抗肿瘤治疗研究，2021.01～2024.12，第二单位项目负责人，排名第二。

8. 吉林省教育厅科学技术研究规划重大项目（JJKH20210828KJ）：多模纳米抗菌材料体系的构建；2021.01～2022.12，主持。

9. 吉林省科技发展计划面上项目(20200201103JC): 基于抑菌COF的光动力协同抗菌体系的构建；2020.01～2022.12，主持。

10. 吉林省教育厅“十三五”科学技术项目(JJKH20170606KJ)：超支化多臂共聚物基因载体对基因及药物的共传递研究，2017.01～2018.12，主持。

11. 中国博士后科学基金（2014M561268）：多功能卟啉聚合物光敏剂在光动力学疗法中的应用，2015.01～2013.02，主持。

12. 吉林省科技发展计划基础项目（20100115）：胶原与PLGA梳型共聚物的合成及其在药物缓释上的应用探索，2010.01～2014.09，主持。

13. 国家自然科学基金青年基金(50903009)：胶原片段接枝脂肪族聚酯类生物降解高分子的合成与医学应用探索； 2010.01～2012.12，主持。

近年来获得的主要奖励：

1. “挑战杯”全国大学生竞赛“揭榜挂帅”专项赛一等奖. 2024，指导教师

2. 吉林省自然科学奖三等奖，阳离子聚合物纳米药物担载体系的构建与研究. 2022，第一.

3. 吉林省自然科学奖二等奖，新型二次电池用碳基电极材料的可控构筑及性能研究. 2021，第三.

4. 吉林省自然科学奖三等奖，以智能聚N-异丙基丙烯酰胺为载体的微纳器件的基础研究. 2015，第二.

5. 吉林省自然科学学术成果二等奖，具有电荷翻转的pH响应基因和抗癌药物共传递体系，2018，第一.

6. 吉林省自然科学学术成果二等奖，高性能锂离子电池电极材料-氮掺杂多孔石墨烯表面负载MnO₂纳米线，2018，第四.

7. 吉林省自然科学学术成果三等奖，功能化聚-N-异丙基丙烯酰胺的构筑及合成，2015，第二.

   近5年来发表的代表性学术论著：

8. Hao Li, Yanwei Li*, Xiaoling Lv, Chong Liu, Nazhen Zhang, Jing Zang, Penghan Yue, Yue Gao, Cong Liu, Yanhui Li*. A Covalent organic framework as photocatalyst for smart conversion between photooxidation and photoreduction and H₂O₂ production in full pH environment. Advanced Materials. 2025 DOI10.1002/adma.202415126 (SCI，IF= 27.3988, I区Top)

9. Dayang Xie, Qiannan Cao, Huapan Fang, Yanhui Li*, Huayu Tian. Applications and challenges of biomedical polymer materials in pulmonary diseases. Chinese Chemical Letters. Accept. 2025 (SCI，IF= 9.4006, I区Top)

10. Penghan Yue, Ling Li, Hao Li, Jiahui Gao, Dayang Xie, Chong Liu, Yanhui Li*, Huayu Tian. Easy preparation of TiO₂/TCPP/CS nanoparticles for effective antibacterial photodynamic therapy. New Journal of Chemistry. 2025, 49(6): 2410-2417 (SCI，2.7001, III区)

11. Chong Liu, Ling Li, Jiahui Gao, Yanwei Li, Nazhen Zhang, Jing Zang, Cong Liu, Zhaopei Guo, Yanhui Li*, Huayu Tian*. The study of antibacterial activity of cationic poly(β-amino ester) regulating by amphiphilic balance. Chinese Chemical Letters. 2024, 26(2): 110118 (SCI，IF= 9.4006, I区Top)

12. Lei Guo, Yixin Tang, Lu Wang, Rui Zhou, Siyuan Wang, Huiqing Xu, Xi Yang, Jizhou Zhang, Jie Chen, Caina Xu,* Yanhui Li,* Huayu Tian. Synergetic Antibacterial Nanoparticles with Broad-Spectrum for Wound Healing and Lung Infection Therapy. Advanced Functional Materials 2024, 2403188 (SCI，IF= 18.5003, I区Top)

13. Zhimin Luo, Yunan Yuan, Ling Li, Dayang Xie, Chong Liu, Tong Li, Zhaopei Guo, Kai Hao*, Yanhui Li*, Huayu Tian*. Facile Synthesis of High Molecular Weight Poly(ethylene glycol)-b-poly(amino acid)s by Relay Polymerization. Biomacromolecules. 2024, 25(2): 1096-1107. (SCI，IF= 6.2001, II区Top)

14. Jiahui Gao, Huixin Li, Penghan Yue, Dayang Xie, Hao Li, Kai Hao*, Yanhui Li*, Huayu Tian*. Multifunctional endogenous small molecule-derived polymer composite nanoparticles for the treatment of acute sepsis therapy. Science China-Materials. 2024, 67(12): 3885-3897 (SCI，IF= IF=6.7996, II区)

15. Ludan Shang, Shan Wu, Xinyu Liu, Yuhan Duan**, Yanhui Li***, Qian Duan. Novel structure and excellent nonlinear optical performance nanocomposite derived from flower-like MOF grown on MoS₂. Dyes and Pigments. 2024, 225: 112089  (SCI，IF=4.0998, II区)

16. Lijuan Ma, Han Wang, Jing Zang, Xinna Wang, Hao Li, Yanwei Li, Yanhui Li*. Multilayer porous Co-Fe bimetallic electrocatalyst based on multi-walled carbon nanotubes for rechargeable zinc-air batteries. Chemistry-An Asian Journal. 2024, 19(20): e202400366 (SCI，IF= 3.5000, III区)

17. Ling Li, Jing Ma, Yuan Cui*, Chong Liu, Hao Li, Dayang Xie, Tinghong Wang*, Yanwei Li, Yanhui Li*. The photosensitizer system based on cationic COF carrier with the loading tetraminoporphyrin and its combined antibacterial effect. New Journal of Chemistry.  2024, 48(32): 14155-14162 (SCI，IF= 2.7001, III区)

18. Wu Suming, Li Yanwei*, Wang Tinghong, Li Hao, Wang Xinna, Ma Lijuan, Zhang Nazhen, Yue Penghan, Li Yanhui*. Design and synthesis of dual functional porphyrin-based COFs as highly selective adsorbent and photocatalyst[J]. Chemical Engineering Journal, 2023: 144135. (SCI，IF= 13.3003, I区Top)

19. Shang Ludan, Li Wenlong, Wang Xinna, Ma Lijuan, Li Ling, Duan Qian*, Li Yanhui*, Preparation of magnetic Fe₃O₄@PDA/CuS core-shell nanocomposite as a green photocatalyst. Synthetic Metals. 2023, 292, 117230. (SCI，IF= 4.000, III区)

20. Wenlong Li, Ludan Shang, Dafei You, Hao Li, Han Wang, Lijuan Ma, Xinna Wang, Yanwei Li*, Yanhui Li*. Fabrication of Fe₃O₄@ Ti-PDA nanoparticles with enhanced photocatalytic activities for degradation of organic dye[J]. Journal of Physics and Chemistry of Solids, 2023, 172: 111047. (SCI，IF= 4.2997, III区)

21. Liu Chong, Li Ling, Guo Zhaopei, Lin lin, Li Yanhui*, Tian Huayu*. PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy[J]. Chinese Journal of Polymer Science, 2022, 41(4): 538-546. (SCI，IF= 4.0998, II区)

22. Zhang Hongxu, Ma Jing, Liu Chong, Li Ling, Xu Caina, Li Yanwei*, Li Yanhui*. Antibacterial activity of guanidinium-based ionic covalent organic framework anchoring Ag nanoparticles[J]. Journal of Hazardous Materials, 2022, 435: 128965. (SCI，IF= 14.2235, I区Top)

23. Li Wenlong, Chi Lin, Zhang Hongxu, Wu Shuming, Wang Han, Luo Zhimin, Li Yanwei*, Li Yanhui*. Fabrication of Ti-PDA nanoparticles with enhanced absorption and photocatalytic activities for hexavalent chromium Cr (VI) removal[J]. Applied Surface Science, 2022, 580: 152168. (SCI，IF= 7.392, I区Top)

24. Huapan Fang, Zhaopei Guo, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li*, Huayu Tian*, Xuesi Chen. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo[J]. Nature Communications, 2021, 12(1): 1-19. (SCI，IF= 17.6939, I区Top)

25. Zhang Yufeng, Wang Dianwei, Liu Feng, Sheng Shu, Zhang Hongxu, Li Wenlong, Li Yanhui*, Tian Huayu*. Enhancing the drug sensitivity of antibiotics on drug-resistant bacteria via the photothermal effect of FeTGNPs. Journal of Controlled Release. 2022, 341: 51-59. (SCI，IF= 11.467, I区Top)

26. Xue Zhang, Zhenjun Si, Yanbing Wang, Yanhui Li*, Caina Xu*, Huayu Tian*. Polymerization and coordination synergistically constructed photothermal agents for macrophages-mediated tumor targeting diagnosis and therapy. Biomaterials. 2021, 264: 120382. (SCI，IF= 15.304, I区Top)

27. Feng Liu, Shu Sheng, Dan Shao, Yongqiang Xiao, Yiling Zhong, Jie Zhou, Chai Hoon Quek, Yanbing Wang, Zhiming Hu, Heshi Liu, Yanhui Li,* Huayu Tian,* Kam W. Leong,* Xuesi Chen. A Cationic Metal-Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management. Nano Letters. 2021, 21, 6: 2461-2469. (SCI，IF= 12.262, I区Top)

28. Yuanji Feng, Jiayan Wu, Jie Chen, Lin Lin,Sijia Zhang, Zhiyu Yang, Pingjie Sun, Yanhui Li*, Huayu Tian*, Xuesi Chen. Targeting dual gene delivery nanoparticles overcomes immune checkpoint blockade induced adaptive resistance and regulates tumor microenvironment for improved tumor immunotherapy. Nano Today. 2021, 38: 101194. (SCI，IF= 18.962, I区Top)

29. Kai Hao, Zhaopei Guo, Lin Lin, Pingjie Sun, Yanhui Li*, Huayu Tian*, Xuesi Chen. Covalent organic framework nanoparticles for anti-tumor gene therapy. Science China Chemistry. 2021, 64(7): 1235-1241. (SCI，IF= 10.138, I区Top)

30. Chong Liu, Zhaopei Guo, Huimin Feng, Lin Lin, Yuan Cui*,Yanhui Li*, Huayu Tian*. Synthesis of copolymers polyethyleneimine-co-polyphenylalanine as gene and drug co-delivery carrier. Macromolecular Bioscience. 2021, 21(5): 2100033(SCI，IF= 5.859, III区)

31. Yufeng Zhang, Jing Ma, Dianwei Wang, Caina Xu, Shu Sheng, Jianfeng Cheng, Changjiang Bao, Yanhui Li*, Huayu Tian*. Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy. Biomaterials science. 2020, 8, 6526–6532. (SCI, IF=7.590, II区)

32. Jing Ma, Jingpeng Zhang, Lin Chi, Chong Liu, Yanhui Li*, Huayu Tian*. Preparation of poly(glutamic acid) shielding micelles self-assembled from polylysine-b-polyphenylalanine for gene and drug codelivery. Chinese Chemical Letters. 2020, 31(6): 1427-1431. (SCI，IF= 9.4006, I区Top)

33. Yanwei Li, Xue Zhang, Jingpeng Zhang, JingMa, LinChi, Nannan Qiu, Yanhui Li*. Synthesis of a biodegradable branched copolymer mPEG-b-PLGA-g-OCol and its pH-sensitive micelle. Materials Science and Engineering: C. 2020, 108: 110455. (SCI，IF= 8.457, II区)

34. Liu Feng, Lin Lin, Sheng Shu , Xu Caina, Wang Yanbing, Zhang Ying, Wang Dianwei, Wu Jiayan, Li Yanhui*, Tian Huayu*, Chen Xuesi. A glutathione-depleting chemodynamic therapy agent with photothermal and photoacoustic properties for tumor theranostics. Nanoscale. 2020, 12, 1349–1355. (SCI，IF= 8.307, II区Top)

35. Dianwei Wang, Zhe Zhang, Lin Lin, Feng Liu, Yanbing Wang, Zhaopei Guo, Yanhui Li*, Huayu Tian*, Xuesi Chen. Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy. Biomaterials. 2019, 223: 119459. (SCI，IF= 15.304, I区Top)

36. Zhichao Dai, Dongni Li, Lin Chi, Yanwei Li, Bo Gao, Nannan Qiu, Qian Duan, Yanhui Li*. Preparation of porphyrin sensitized three layers magnetic nanocomposite Fe₃O₄@SiO₂@TiO₂ as an efficient photocatalyst. Materials Letters. 2019, 241: 239-242. (SCI，IF= 3.574, III区)

社会任职：

厦门市聚合物加工原理与应用重点实验室主任，厦门市新材料产业协会高分子专业委员会专家委员，光电材料器件网专家委员会常务理事，科学家智库光电材料专家委员会常务理事，中国生物材料学会烧创伤创面修复材料分会委员，全国普通高等学校本科教育教学评估专家，凡科优秀评审专家，教育部学位中心论文评审专家。

联系方式

电话：13578901583

Email：liyanhui@xmut.edu.cn

通讯地址：福建省厦门市集美区理工路600号金沙9159游乐场(中国)有限公司-环球百科

邮    编：361024

高分子材料涉及到的研究及应用领域非常广泛，欢迎希望从事生物医用高分子、能源高分子、光电功能高分子、环保高分子等材料的同学加入我的团队，未来一起从事相关的科学和应用研究。